Article
Mutations associated with sulfadoxine-pyrimethamine and chlorproguanil resistance in Plasmodium falciparum isolates from Blantyre, Malawi.
Antimicrobial agents and chemotherapy - 1 Sept 2005
Alker Alisa P, Mwapasa Victor, Purfield Anne, Rogerson Stephen J, Molyneux Malcolm E, Kamwendo Deborah D, Tadesse Eyob, Chaluluka Ebbie, Meshnick Steven R
Abstract excerpt
We conducted a prevalence study of mutations in Plasmodium falciparum that are associated with antifolate resistance in Blantyre, Malawi. The dihydrofolate reductase 164-Leu mutation, which confers resistance to both pyrimethamine and chlorproguanil, was found in 4.7% of the samples. Previously unreported mutations in dihydropteroate synthase were also found.
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