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Article

Plasmodium falciparum strains harboring dihydrofolate reductase with the I164L mutation are absent in Malawi and Zambia even under antifolate drug pressure.

Antimicrobial agents and chemotherapy - 1 Nov 2008

Ochong Edwin, Bell David J, Johnson David J, D'Alessandro Umberto, Mulenga Modest, Muangnoicharoen Sant, Van Geertruyden Jean-Pierre, Winstanley Peter A, Bray Patrick G, Ward Stephen A, Owen Andrew

Abstract excerpt

The Plasmodium falciparum dihydrofolate reductase (PfDHFR) enzyme is the target of pyrimethamine, a component of the antimalarial pyrimethamine-sulfadoxine. Resistance to this drug is associated primarily with mutations in the Pfdhfr gene. The I164L mutant allele is of particular interest, because strains possessing this mutation are highly resistant to pyrimethamine and to chlorproguanil, a component of...

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Identifiers

PMID: 18725445
DOI: 10.1128/AAC.00431-08
PMCID: PMC2573156

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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