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Article

BMP-7 opposes TGF-beta1-mediated collagen induction in mouse pulmonary myofibroblasts through Id2.

American journal of physiology. Lung cellular and molecular physiology - 1 Jan 2006

Izumi Nobuhiro, Mizuguchi Shinjiro, Inagaki Yutaka, Saika Shizuya, Kawada Norifumi, Nakajima Yuji, Inoue Kiyotoshi, Suehiro Shigefumi, Friedman Scott L, Ikeda Kazuo

Abstract excerpt

Mesenchymal cells, primarily fibroblasts and myofibroblasts, are the principal matrix-producing cells during pulmonary fibrogenesis. Transforming growth factor (TGF)-beta signaling plays an important role in stimulating the expression of type I collagen of these cells. Bone morphogenetic protein (BMP)-7, a member of the TGF-beta superfamily, has been reported to oppose the fibrogenic activity of TGF-beta1. Here,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16126788
DOI: 10.1152/ajplung.00171.2005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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