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Article

Insights into the conformational changes of several human lysozyme variants associated with hereditary systemic amyloidosis.

Biotechnology progress - 1 Jan 2000

Liu Hsuan-Liang, Wu Yi-Ching, Zhao Jian-Hua, Liu Yi-Fan, Huang Chi-Hung, Fang Hsu-Wei, Ho Yih

Abstract excerpt

In this study, various ethanol- and temperature-induced molecular dynamics simulations were conducted to investigate the conformational changes of several human lysozyme variants (I56T, D67H, and T70N) associated with hereditary systemic amyloidosis. The results show that these variants are all more sensitive to conditions affecting the structural integrity of this protein. The structural analyses of these...

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PMID: 17269695
DOI: 10.1021/bp060264a

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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