Article
Genetic polymorphisms of alcohol and aldehyde dehydrogenase, dopamine and serotonin transporters in familial and non-familial alcoholism.
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology - 1 Feb 2006
Choi Ihn-Geun, Kee Baik Seok, Son Hyun-Gyun, Ham Byung Joo, Yang Byung-Hwan, Kim Seok Hyeon, Lee Jun-Suk, Son Bong Ki, Lee Byeong-Yong, Lee Sang-Yeol, Chai Young-Gyu, Shin Hyoung Doo
Abstract excerpt
One hundred and eleven male patients with alcohol dependence and 123 nonalcoholic healthy men were tested for the genetic polymorphisms of alcohol dehydrogenase 2 (ADH2), aldehyde dehydrogenase 2 (ALDH2), serotonin transporter (5-HTT) and dopamine transporter (DAT1). There were significant differences in genotype frequencies of ADH2 C992G and A13543G SNPs between alcoholic patients with family history of alcohol...
Topics
- Adult
- Alcohol Dehydrogenase
- Alcoholism
- Aldehyde Dehydrogenase
- Alleles
- DNA
- Dopamine Plasma Membrane Transport Proteins
- Family
- Gene Frequency
- Genotype
- Humans
- Isoenzymes