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Article

Evidence for a CDK4-dependent checkpoint in a conditional model of cellular senescence.

Cell cycle (Georgetown, Tex.) - 1 Jan 2015

Brookes Sharon, Gagrica Sladjana, Sanij Elaine, Rowe Janice, Gregory Fiona J, Hara Eiji, Peters Gordon

Abstract excerpt

Cellular senescence, the stable cell cycle arrest elicited by various forms of stress, is an important facet of tumor suppression. Although much is known about the key players in the implementation of senescence, including the pRb and p53 axes and the cyclin dependent kinase inhibitors p16(INK4a) and p21(CIP1), many details remain unresolved. In studying conditional senescence in human fibroblasts that express a...

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Source

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Identifiers

PMID: 25695870
DOI: 10.1080/15384101.2015.1010866
PMCID: PMC4613988

Genes

CDK4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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