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Article

Laminin Reduces Expression of the Human α6 Integrin Subunit Gene by Altering the Level of the Transcription Factors Sp1 and Sp3

25 Jul 2007

Abstract excerpt

PURPOSE: Damage to the corneal epithelium results in the massive secretion of fibronectin (FN) shortly after corneal injury, which is later replaced by the secretion of laminin (LM). Laminin is recognized by receptors (alpha6beta1 and alpha6beta4) that belong to the integrin family. The authors characterized the regulatory influence exerted by laminin on the Sp1/Sp3-mediated alpha6 gene promoter function....

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PMID: 17652716
DOI: 10.1167/iovs.07-0016

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