Article
Lack of support for the association between GAD2 polymorphisms and severe human obesity.
PLoS biology - 1 Sept 2005
Swarbrick Michael M, Waldenmaier Björn, Pennacchio Len A, Lind Denise L, Cavazos Martha M, Geller Frank, Merriman Raphael, Ustaszewska Anna, Malloy Mary, Scherag André, Hsueh Wen-Chi, Rief Winfried, Mauvais-Jarvis Franck, Pullinger Clive R, Kane John P, Dent Robert, McPherson Ruth, Kwok Pui-Yan, Hinney Anke, Hebebrand Johannes, Vaisse Christian
Abstract excerpt
The demonstration of association between common genetic variants and chronic human diseases such as obesity could have profound implications for the prediction, prevention, and treatment of these conditions. Unequivocal proof of such an association, however, requires independent replication of initial positive findings. Recently, three (-243 A>G, +61450 C>A, and +83897 T>A) single nucleotide polymorphisms (SNPs)...
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