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Article

Characterizing sterol defect suppressors uncovers a novel transcriptional signaling pathway regulating zymosterol biosynthesis.

The Journal of biological chemistry - 28 Oct 2005

Germann Melody, Gallo Christina, Donahue Timothy, Shirzadi Reza, Stukey Joseph, Lang Silvia, Ruckenstuhl Christoph, Oliaro-Bosso Simonetta, McDonough Virginia, Turnowsky Friederike, Balliano Gianni, Nickels Joseph T

Abstract excerpt

erg26-1ts cells harbor defects in the 4alpha-carboxysterol-C3 dehydrogenase activity necessary for conversion of 4,4-dimethylzymosterol to zymosterol. Mutant cells accumulate toxic 4-carboxysterols and are inviable at high temperature. A genetic screen aimed at cloning recessive mutations remediating the temperature sensitive growth defect has resulted in the isolation of four complementation groups, ets1-4...

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Source

Identifiers

PMID: 16120615
DOI: 10.1074/jbc.M504978200

Genes

ETS1
ETS2

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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