Article
Prion diseases: what is the neurotoxic molecule?
Neurobiology of disease - 1 Oct 2001
Chiesa R, Harris D A
Abstract excerpt
A great deal of effort has been devoted during the past 20 years to defining the chemical nature of prions, the infectious agents responsible for transmissible spongiform encephalopathies. In contrast, much less attention has been paid to elucidating how prions actually damage the central nervous system. Although it is commonly assumed that PrP(Sc), the protein constituent of infectious prions, is the primary...
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