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Article

PrP mutants with different numbers of octarepeat sequences are more susceptible to the oxidative stress.

Science in China. Series C, Life sciences - 1 Jul 2008

An Run, Dong Chenfang, Lei Yanjun, Han Lu, Li Ping, Chen Jianming, Wang Guirong, Shi Qi, Gao Chen, Jiang Huiying, Zhou Wei, Han Jun, Chu Yonglie, Dong Xiaoping

Abstract excerpt

One of the physiological functions of cellular prion protein (PrP(C)) is believed to work as a cellular resistance to oxidative stress, in which the octarepeats region within PrP plays an important role. However, the detailed mechanism is less clear. In this study, the expressing plasmids of wild-type PrP (PrP-PG5) and various PrP mutants containing 0 (PrP-PG0), 9 (PrP-PG9) and 12 (PrP-PG12) octarepeats were...

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Identifiers

PMID: 18622746
DOI: 10.1007/s11427-008-0062-4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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