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Article

Synthetic lethal screen.

Methods in molecular biology (Clifton, N.J.) - 1 Jan 2006

Barbour Leslie, Xiao Wei

Abstract excerpt

The synthetic lethal screen is a method of isolating novel mutants whose survival is dependent on a gene of interest. Combining the colony-color assay with a synthetic lethal screen offers a means to visually detect a mutant that depends on a plasmid for survival. Screening for synthetic lethals can be achieved in four steps. First, the gene of interest must be mutated in a strain harboring the ade2 ade3/ade8...

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PMID: 16118433
DOI: 10.1385/1-59259-958-3:161

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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