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Characterization of genes that are synthetically lethal with ade3 or leu2 in Saccharomyces cerevisiae.

Yeast (Chichester, England) - 30 Jan 2002

Nigavekar Shraddha S, Cannon John F

Abstract excerpt

Combinations of two non-lethal mutations that result in cell death are synthetically lethal. Such a genetic relationship suggests a functional interaction between the corresponding gene products. Frequently, an ade2 ade3 colony-sectoring assay is used to screen for synthetic lethal mutants. In these screens, mutants are sought that fail to lose a plasmid that bears a gene of interest. However, a subset of mutants...

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PMID: 11788966
DOI: 10.1002/yea.807

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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