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Article

Immunomodulatory dendritic cells require autologous serum to circumvent nonspecific immunosuppressive activity in vivo.

Blood - 15 Dec 2005

Haase Claus, Ejrnaes Mette, Juedes Amy E, Wolfe Tom, Markholst Helle, von Herrath Matthias G

Abstract excerpt

In immunotherapy, dendritic cells (DCs) can be used as powerful antigen-presenting cells to enhance or suppress antigen-specific immunity upon in vivo transfer in mice or humans. However, to generate sufficient numbers of DCs, most protocols include an ex vivo culture step, wherein the cells are exposed to heterologous serum and/or antigenic stimuli. In mouse models of virus infection and virus-induced...

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PMID: 16118326
DOI: 10.1182/blood-2005-03-0975
PMCID: PMC1895252

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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