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Article

NOD/scid IL-2Rg(null) mice: a preclinical model system to evaluate human dendritic cell-based vaccine strategies in vivo.

Journal of translational medicine - 25 Feb 2012

Spranger Stefani, Frankenberger Bernhard, Schendel Dolores J

Abstract excerpt

BACKGROUND: To date very few systems have been described for preclinical investigations of human cellular therapeutics in vivo. However, the ability to carry out comparisons of new cellular vaccines in vivo would be of substantial interest for design of clinical studies. Here we describe a humanized mouse model to assess the efficacy of various human dendritic cell (DC) preparations. Two reconstitution regimes of...

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Identifiers

PMID: 22364226
DOI: 10.1186/1479-5876-10-30
PMCID: PMC3309948

Genes

TLR7
TLR3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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