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Article

MgcRacGAP regulates cortical activity through RhoA during cytokinesis.

Experimental cell research - 15 Feb 2004

Lee Jae-Seon, Kamijo Keiju, Ohara Naoya, Kitamura Toshio, Miki Toru

Abstract excerpt

Although Rho GTPases regulate multiple cellular events, their role in cell division is still obscure. Here we show that expression of a GTPase-activating protein (GAP)-deficient mutant (R386A) of the Rho regulator MgcRacGAP induces abnormal cortical activity during cytokinesis in U2OS cells. Multiple large blebs were observed in cells expressing MgcRacGAP R386A from the onset of anaphase to the late stage of cell...

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Identifiers

PMID: 14729465
DOI: 10.1016/j.yexcr.2003.10.015

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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