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Article

The homophilic binding of junctional adhesion molecule-C mediates tumor cell-endothelial cell interactions.

The Journal of biological chemistry - 28 Oct 2005

Santoso Sentot, Orlova Valeria V, Song Kaimei, Sachs Ulrich J, Andrei-Selmer Cornelia L, Chavakis Triantafyllos

Abstract excerpt

The junctional adhesion molecule C (JAM-C) was recently shown to undergo a heterophilic interaction with the leukocyte beta2 integrin Mac-1, thereby mediating interactions between vascular cells in inflammatory cell recruitment. Here, the homophilic interaction of JAM-C is presented and functionally characterized to mediate tumor cell-endothelial cell interactions. Recombinant soluble JAM-C in fluid phase bound...

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Source

Identifiers

PMID: 16118203
DOI: 10.1074/jbc.M505059200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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