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Article

Cis-dimerization mediates function of junctional adhesion molecule A.

Molecular biology of the cell - 1 May 2008

Severson Eric A, Jiang Liangyong, Ivanov Andrei I, Mandell Kenneth J, Nusrat Asma, Parkos Charles A

Abstract excerpt

Junctional adhesion molecule-A (JAM-A) is a transmembrane component of tight junctions that has been proposed to play a role in regulating epithelial cell adhesion and migration, yet mechanistic structure-function studies are lacking. Although biochemical and structural studies indicate that JAM-A forms cis-homodimers, the functional significance of dimerization is unclear. Here, we report the effects of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18272784
DOI: 10.1091/mbc.e07-09-0869
PMCID: PMC2366836

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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