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The Junctional Adhesion Molecule‐B regulates JAM‐C‐dependent melanoma cell metastasis

12 Oct 2012

Abstract excerpt

Metastasis is a major clinical issue and results in poor prognosis for most cancers. The Junctional Adhesion Molecule-C (JAM-C) expressed by B16 melanoma and endothelial cells has been involved in metastasis of tumor cells through homophilic JAM-C/JAM-C trans-interactions. Here, we show that JAM-B expressed by endothelial cells contributes to murine B16 melanoma cells metastasis through its interaction with JAM-C...

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PMID: 23068611
DOI: 10.1016/j.febslet.2012.10.005

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