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Article

Disentangling linkage disequilibrium and linkage from dense single-nucleotide polymorphism trio data.

Genetics - 1 Dec 2005

Clarke Geraldine M, Cardon Lon R

Abstract excerpt

Parent-offspring trios are widely collected for disease gene-mapping studies and are being extensively genotyped as part of the International HapMap Project. With dense maps of markers on trios, the effects of LD and linkage can be separated, allowing estimation of recombination rates in a model-free setting. Here we define a model-free multipoint method on the basis of dense sequence polymorphism data from...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16118185
DOI: 10.1534/genetics.105.047431
PMCID: PMC1456135

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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