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Article

High-resolution population-specific recombination rates and their effect on phasing and genotype imputation.

European journal of human genetics : EJHG - 1 Apr 2021

Hassan Shabbeer, Surakka Ida, Taskinen Marja-Riitta, Salomaa Veikko, Palotie Aarno, Wessman Maija, Tukiainen Taru, Pirinen Matti, Palta Priit, Ripatti Samuli

Abstract excerpt

Previous research has shown that using population-specific reference panels has a significant effect on downstream population genomic analyses like haplotype phasing, genotype imputation, and association, especially in the context of population isolates. Here, we developed a high-resolution recombination rate mapping at 10 and 50 kb scale using high-coverage (20-30×) whole-genome sequenced data of 55 family trios...

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Identifiers

PMID: 33249422
DOI: 10.1038/s41431-020-00768-8
PMCID: PMC8114909

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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