An empirical comparison of case-control and trio based study designs in high throughput association mapping.

doi:10.1136/jmg.2005.036020

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Article

An empirical comparison of case-control and trio based study designs in high throughput association mapping.

Journal of medical genetics - 1 Jul 2006

Hintsanen P, Sevon P, Onkamo P, Eronen L, Toivonen H

Abstract excerpt

Motivated by high throughput genotyping technology, our aim in this study was to experimentally compare the power and accuracy of case-control and family trio based approaches for haplotype based, large scale, association gene mapping. We compared trio based and case-control study designs in diff...

Topics

Algorithms
Case-Control Studies
Chromosome Mapping
Databases, Factual
Genetic Diseases, Inborn
Genotype
Humans
Research Design

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