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Article

Suppression of progressive loss of coat color in microphthalmia-vitiligo mutant mice.

The Journal of investigative dermatology - 1 Sept 2005

Kurita Kei, Nishito Maki, Shimogaki Hisao, Takada Koji, Yamazaki Hidetoshi, Kunisada Takahiro

Abstract excerpt

The coat color of C57BL/6-Mitfvit/vit mice whitens with age, because of a one-nucleotide mutation in the DNA-binding region of the microphthalmia-associated transcription factor (MITF), which plays an important role in melanocyte growth and differentiation. To investigate the signals regulating MITF function, we prepared transgenic mice expressing three of the external signals that are important for melanocyte...

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Source

Identifiers

PMID: 16117796
DOI: 10.1111/j.0022-202X.2005.23861.x

Genes

HGF
MITF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Suppression of progressive loss of coat color in microphthalmia-vitiligo mutant mice.PMID 16117796Read ↗

Regional Fluctuation in the Functional Consequence of LINE-1 Insertion in the Mitf Gene: The Black Spotting Phenotype Arisen from the Mitfmi-bw Mouse Lacking Melanocytes.Semantic proximity Read ↗

Molecular basis of mouse microphthalmia (mi) mutations helps explain their developmental and phenotypic consequences.Semantic proximity Read ↗

The role of MITF phosphorylation sites during coat color and eye development in mice analyzed by bacterial artificial chromosome transgene rescue.Semantic proximity Read ↗

Mutations in microphthalmia, the mouse homolog of the human deafness gene MITF, affect neuroepithelial and neural crest-derived melanocytes differently.Semantic proximity Read ↗

The vit gene maps to the mi (microphthalmia) locus of the laboratory mouse.Semantic proximity Read ↗

Effects of the white allele of the mi locus on coat pigmentation in chimeric mice.Semantic proximity Read ↗

Insight into the microphthalmia gene.Semantic proximity Read ↗

Pten deficiency in melanocytes results in resistance to hair graying and susceptibility to carcinogen-induced melanomagenesis.Semantic proximity Read ↗

Transient overexpression of the Microphthalmia gene in the eyes of Microphthalmia vitiligo mutant mice.Semantic proximity Read ↗

Effect of the mutant microphthalmia-associated transcription factor found in Tietz syndrome on the in vitro development of mast cells.Semantic proximity Read ↗

Melanocyte development in vivo and in neural crest cell cultures: crucial dependence on the Mitf basic-helix-loop-helix-zipper transcription factor.Semantic proximity Read ↗

Mutation of the MITF gene in albinism-deafness syndrome (Tietz syndrome).Semantic proximity Read ↗

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