Article
Transient overexpression of the Microphthalmia gene in the eyes of Microphthalmia vitiligo mutant mice.
Developmental dynamics : an official publication of the American Association of Anatomists - 1 Nov 1998
Bora N, Conway S J, Liang H, Smith S B
Abstract excerpt
The murine microphthalmia gene (Mitf) encodes a basic helix-loop-helix transcription factor thought to regulate transcription of genes encoding proteins of the pigmentation pathway. It may promote pigment cell survival and development. The protein encoded by Mitf appears to be critical for eye de...
Topics
- Alleles
- Animals
- DNA-Binding Proteins
- Eye Abnormalities
- Female
- Gene Expression Regulation, Developmental
- Helix-Loop-Helix Motifs
- Homozygote
- In Situ Hybridization
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Mutant Strains
- Microphthalmia-Associated Transcription Factor