Modulation of the age at onset of Parkinson's disease by apolipoprotein E genotypes.

doi:10.1002/ana.410420417

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Article

Modulation of the age at onset of Parkinson's disease by apolipoprotein E genotypes.

Annals of neurology - 1 Oct 1997

Zareparsi S, Kaye J, Camicioli R, Grimslid H, Oken B, Litt M, Nutt J, Bird T, Schellenberg G, Payami H

Abstract excerpt

Parkinson's disease (PD) patients often develop dementia, and Alzheimer's disease (AD) patients frequently develop parkinsonian signs. The apolipoprotein E epsilon4 allele is associated with increased risk and earlier onset of AD. We studied 137 unrelated white PD patients. Those with epsilon4 ha...

Topics

Age of Onset
Aged
Apolipoprotein E2
Apolipoprotein E3
Apolipoprotein E4
Apolipoproteins E
Female
Genotype
Humans
Male
Middle Aged
Parkinson Disease

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