Article
Src-mediated phosphorylation regulates subcellular distribution and activity of human inducible nitric oxide synthase.
Oncogene - 12 Jan 2006
Hausel P, Latado H, Courjault-Gautier F, Felley-Bosco E
Abstract excerpt
Inducible nitric oxide synthase (iNOS) expression is regulated at both the transcriptional and post-transcriptional level in epithelial cells. The aim of this study was to characterize the effects of tyrosine phosphorylation on iNOS activity. In a human intestinal epithelial cell line stimulated with cytokines, tyrosine phosphorylation of human iNOS protein was observed after 30 min exposure to pervanadate (PV),...
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