Article
Transcriptional regulation of the human iNOS gene by IL-1beta in endothelial cells.
Molecular medicine (Cambridge, Mass.) - 1 May 2001
Kolyada A Y, Madias N E
Abstract excerpt
BACKGROUND: Vascular endothelium participates in the control of vascular tone and function via the release of nitric oxide (NO) by the endothelial-type NO synthase (eNOS). Inducible NO synthase (iNOS) expression in endothelial cells occurs in many clinical conditions following induction by lipopolysaccharide or cytokines and generates large quantities of NO that result in endothelial cell activation and...
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