Article
Hyper-activation of pp60Src limits nitric oxide signaling by increasing asymmetric dimethylarginine levels during acute lung injury.
Free radical biology & medicine - 1 Jan 2017
Kumar Sanjiv, Sun Xutong, Noonepalle Satish Kumar, Lu Qing, Zemskov Evgeny, Wang Ting, Aggarwal Saurabh, Gross Christine, Sharma Shruti, Desai Ankit A, Hou Yali, Dasarathy Sridevi, Qu Ning, Reddy Vijay, Lee Sung Gon, Cherian-Shaw Mary, Yuan Jason X-J, Catravas John D, Rafikov Ruslan, Garcia Joe G N, Black Stephen M
Abstract excerpt
The molecular mechanisms by which the endothelial barrier becomes compromised during lipopolysaccharide (LPS) mediated acute lung injury (ALI) are still unresolved. We have previously reported that the disruption of the endothelial barrier is due, at least in part, to the uncoupling of endothelial nitric oxide synthase (eNOS) and increased peroxynitrite-mediated nitration of RhoA. The purpose of this study was to...
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