Article
A recombined haplotype in the major histocompatibility region contains a cluster of genes conferring high susceptibility to ulcerative colitis in the Spanish population.
Inflammatory bowel diseases - 1 Sept 2005
Fernández Laura, Núñez Concepción, Mendoza Juan Luis, Urcelay Elena, Fernández-Arquero Miguel, Taxonera Carlos, Díaz-Rubio Manuel, de la Concha Emilio G, Martínez Alfonso
Abstract excerpt
BACKGROUND: The most consistently described associations in ulcerative colitis (UC) have been with human leukocyte antigen (HLA) class II alleles. Our aim was to look for associations among distinct genetic polymorphisms in the major histocompatibility complex (MHC) that might play a role in determining the susceptibility to UC and especially to the extensive form of the disease. METHODS: A case-control study was...
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