Article
T cells expressing receptors of different affinity for antigen ligands reveal a unique role for p59fyn in T cell development and optimal stimulation of T cells by antigen.
Journal of immunology (Baltimore, Md. : 1950) - 1 Jun 1998
Utting O, Teh S J, Teh H S
Abstract excerpt
Signaling from the TCR involves the protein tyrosine kinase p59fyn (Fyn). Previous studies have shown that T cell development occurs normally in Fyn-/- mice. In this study, we investigated the requirement for Fyn in the development and function of T cells expressing either the transgenic 2C TCR,...
Topics
- Animals
- Antigens
- CD8 Antigens
- Cell Differentiation
- Female
- H-Y Antigen
- Immunophenotyping
- Ligands
- Lymph Nodes
- Lymphocyte Activation
- Male
- Mice
- Mice, Inbred C57BL
- Mice, Inbred DBA
- Mice, Knockout
- Mice, Transgenic
- Mutation
- Protein-Tyrosine Kinases