Article
Rapid PrP(Sc) detection in lymphoid tissue and application to scrapie surveillance of fallen stock in Japan: variable PrP(Sc) accumulation in palatal tonsil in natural scrapie.
Microbiology and immunology - 1 Jan 2005
Shimada Kimi, Hayashi Hiroko K, Ookubo Yuka, Iwamaru Yoshifumi, Imamura Morikazu, Takata Masuhiro, Schmerr Mary Jo, Shinagawa Morikazu, Yokoyama Takashi
Abstract excerpt
Rapid western blot (WB) procedure for an abnormal isoform of prion protein (PrP(Sc) ) detection in lymphoid tissues was established and has been applied to the surveillance of fallen stock. In this program, brain and palatal tonsil were examined by WB and three cases of sheep scrapie were detected. While one clinically scrapie-infected sheep harbored PrP(Sc) in the brain and palatal tonsil, the two sheep in the...
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