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Article

TGF-β1 Gene Silencing for Treating Liver Fibrosis

23 Apr 2009

Abstract excerpt

Small interfering RNA (siRNA) and short hairpin RNA (shRNA) targeting different regions of transforming growth factor beta1 (TGF-beta1) mRNA were designed and the silencing effect was determined after transfection into immortalized rat liver stellate cells (HSC-T6). There was not only significant decrease in TGF-beta1, tissue inhibitor of metalloproteinase 1 (TIMP-1), alpha-smooth muscle actin (alpha-SMA) and...

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Share to Hepatitis B Virus Studies
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PMID: 19388665
DOI: 10.1021/mp9000469

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