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Article

Identification of the gene transcription and apoptosis mediated by TGF‐β‐Smad2/3‐Smad4 signaling

24 Oct 2007

Abstract excerpt

Transforming growth factor-beta (TGF-beta) signaling is known to depend on the formation of Smad2/3-Smad4 transcription regulatory complexes. However, the signaling functions of Smad2/3-Smad4 during TGF-beta-induced responses are obscure as TGF-beta also initiates a number of other signaling pathways. In this study, we systematically assessed the contribution of TGF-beta-Smad2/3-Smad4 signaling to both target...

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PMID: 17960585
DOI: 10.1002/jcp.21325

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