Article
Genetic polymorphisms of methylenetetrahydrofolate reductase and aldehyde dehydrogenase 2, alcohol use and risk of colorectal adenomas: Self-Defense Forces Health Study.
Cancer science - 1 Aug 2005
Hirose Maho, Kono Suminori, Tabata Shinji, Ogawa Shinsaku, Yamaguchi Keizo, Mineshita Masamichi, Hagiwara Tomoko, Yin Guang, Lee Kyong-Yeon, Tsuji Akiko, Ikeda Noriaki
Abstract excerpt
Methylenetetrahydrofolate reductase is a key enzyme in folate metabolism, which affects DNA synthesis and methylation and is possibly linked to colorectal carcinogenesis. Alcohol and acetaldehyde have an adverse effect on folate metabolism. This study investigated the relationship of functional MTHFR C677T and ALDH2 polymorphisms to colorectal adenomas with reference to alcohol consumption in a case-control study...
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