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Article

Methylenetetrahydrofolate reductase C677T and A1298C polymorphisms and colorectal cancer: the Fukuoka Colorectal Cancer Study.

Cancer science - 1 Nov 2004

Yin Guang, Kono Suminori, Toyomura Kengo, Hagiwara Tomoko, Nagano Jun, Mizoue Tetsuya, Mibu Ryuichi, Tanaka Masao, Kakeji Yoshihiro, Maehara Yoshihiko, Okamura Takeshi, Ikejiri Koji, Futami Kitaroh, Yasunami Yohichi, Maekawa Takafumi, Takenaka Kenji, Ichimiya Hitoshi, Imaizumi Nobutoshi

Abstract excerpt

Methylenetetrahydrofolate reductase (MTHFR) is a key enzyme regulating folate metabolism, which affects DNA synthesis and methylation. This study investigated the relation of MTHFR C677T and A1298C polymorphisms to colorectal cancer in a case-control study in Fukuoka, Japan. The subjects comprised 685 incident cases of histologically confirmed colorectal adenocarcinomas and 778 community controls selected...

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Identifiers

PMID: 15546509
DOI: 10.1111/j.1349-7006.2004.tb02201.x
PMCID: PMC11159398

Genes

MTHFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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