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Genetic polymorphism of cholesterol 7alpha-hydroxylase (CYP7A1) and colorectal adenomas: Self Defense Forces Health Study.

Cancer science - 1 May 2006

Tabata Shinji, Yin Guang, Ogawa Shinsaku, Yamaguchi Keizo, Mineshita Masamichi, Kono Suminori

Abstract excerpt

Bile acids have long been implicated in colorectal carcinogenesis, but epidemiological evidence is limited. Cholesterol 7alpha-hydroxylase (CYP7A1) is the rate-limiting enzyme producing bile acids from cholesterol. A recent case-control study showed a decreased risk of proximal colon cancer associated with the CC genotype of the CYP7A1 A-203C polymorphism. The present study examined the relationship between the...

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Identifiers

PMID: 16630139
DOI: 10.1111/j.1349-7006.2006.00182.x
PMCID: PMC11159969

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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