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Article

Differential regulation of β-catenin-mediated transcription via N- and C-terminal co-factors governs identity of murine intestinal epithelial stem cells.

Nature communications - 1 Mar 2021

Borrelli Costanza, Valenta Tomas, Handler Kristina, Vélez Karelia, Gurtner Alessandra, Moro Giulia, Lafzi Atefeh, Roditi Laura de Vargas, Hausmann George, Arnold Isabelle C, Moor Andreas E, Basler Konrad

Abstract excerpt

The homeostasis of the gut epithelium relies upon continuous renewal and proliferation of crypt-resident intestinal epithelial stem cells (IESCs). Wnt/β-catenin signaling is required for IESC maintenance, however, it remains unclear how this pathway selectively governs the identity and proliferative decisions of IESCs. Here, we took advantage of knock-in mice harboring transgenic β-catenin alleles with mutations...

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Identifiers

PMID: 33649334
DOI: 10.1038/s41467-021-21591-9
PMCID: PMC7921392

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