Article
Cationic sites on granzyme B contribute to cytotoxicity by promoting its uptake into target cells.
Molecular and cellular biology - 1 Sept 2005
Bird Catherina H, Sun Jiuru, Ung Kheng, Karambalis Diana, Whisstock James C, Trapani Joseph A, Bird Phillip I
Abstract excerpt
Granzyme B (GrB) is a key effector of cytotoxic lymphocyte-mediated cell death. It is delivered to target cells bound to the proteoglycan serglycin, but how it crosses the plasma membrane and accesses substrates in the cytoplasm is poorly understood. Here we identify two cationic sequences on GrB that facilitate its binding and uptake. Mutation of cationic sequence 1 (cs1) prevents accumulation of GrB in a...
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