Article
Intracellular serine protease inhibitor SERPINB4 inhibits granzyme M-induced cell death.
PloS one - 1 Jan 2011
de Koning Pieter J A, Kummer J Alain, de Poot Stefanie A H, Quadir Razi, Broekhuizen Roel, McGettrick Anne F, Higgins Wayne J, Devreese Bart, Worrall D Margaret, Bovenschen Niels
Abstract excerpt
Granzyme-mediated cell death is the major pathway for cytotoxic lymphocytes to kill virus-infected and tumor cells. In humans, five different granzymes (i.e. GrA, GrB, GrH, GrK, and GrM) are known that all induce cell death. Expression of intracellular serine protease inhibitors (serpins) is one of the mechanisms by which tumor cells evade cytotoxic lymphocyte-mediated killing. Intracellular expression of...
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