Article
Hyperglycemia and reactive oxygen species mediate apoptosis in aortic endothelial cells through Janus kinase 2.
Vascular pharmacology - 1 Nov 2005
Tawfik Amany, Jin Liming, Banes-Berceli Amy K L, Caldwell Ruth B, Ogbi Safia, Shirley Amanda, Barber Dwayne, Catravas John D, Stern David M, Fulton David, Caldwell R William, Marrero Mario B
Abstract excerpt
The generation of reactive oxygen species (ROS) has been implicated in the perturbation of endothelial function and cell death. However, the specific signaling pathways which mediate and modifying this response have not been fully elucidated. Therefore, in this study we tested the hypothesis that activation of JAK2 is involved in the aortic endothelial cell (EC) response to ROS. When ECs were exposed to HG (25...
Topics
- Adenoviridae
- Aorta
- Apoptosis
- Blotting, Western
- Cell Survival
- Cells, Cultured
- Endothelial Cells
- Humans
- Hydrogen Peroxide
- Hyperglycemia
- Janus Kinase 2
- Microscopy, Fluorescence
- Mutation