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Article

Conserved intramolecular disulfide bond is critical to trafficking and fate of ATP-binding cassette (ABC) transporters ABCB6 and sulfonylurea receptor 1 (SUR1)/ABCC8.

The Journal of biological chemistry - 11 Mar 2011

Fukuda Yu, Aguilar-Bryan Lydia, Vaxillaire Martine, Dechaume Aurelie, Wang Yao, Dean Michael, Moitra Karobi, Bryan Joseph, Schuetz John D

Abstract excerpt

The ATP-binding cassette (ABC) transporter ABCB6 is a mitochondrial porphyrin transporter that activates porphyrin biosynthesis. ABCB6 lacks a canonical mitochondrial targeting sequence but reportedly traffics to other cellular compartments such as the plasma membrane. How ABCB6 reaches these destinations is unknown. In this study, we show that endogenous ABCB6 is glycosylated in multiple cell types, indicating...

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Identifiers

PMID: 21199866
DOI: 10.1074/jbc.M110.174516
PMCID: PMC3048732

Genes

ABCB6
ABCC8

Provenance

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