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Article

Interaction with the 5D3 monoclonal antibody is regulated by intramolecular rearrangements but not by covalent dimer formation of the human ABCG2 multidrug transporter.

The Journal of biological chemistry - 19 Sept 2008

Ozvegy-Laczka Csilla, Laczkó Rozália, Hegedus Csilla, Litman Thomas, Várady György, Goda Katalin, Hegedus Tamás, Dokholyan Nikolay V, Sorrentino Brian P, Váradi András, Sarkadi Balázs

Abstract excerpt

Human ABCG2 is a plasma membrane glycoprotein working as a homodimer or homo-oligomer. The protein plays an important role in the protection/detoxification of various tissues and may also be responsible for the multidrug-resistant phenotype of cancer cells. In our previous study we found that the 5D3 monoclonal antibody shows a function-dependent reactivity to an extracellular epitope of the ABCG2 transporter. In...

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Share to ATP Binding Cassette Transporter, Subfamily G, Member 2
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Identifiers

PMID: 18644784
DOI: 10.1074/jbc.M803230200
PMCID: PMC3258862

Genes

ABCG2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Interaction with the 5D3 monoclonal antibody is regulated by intramolecular rearrangements but not by covalent dimer formation of the human ABCG2 multidrug transporter.PMID 18644784Read ↗

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