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Article

Formation of two intramolecular disulfide bonds is necessary for ApoA-I-dependent cholesterol efflux mediated by ABCA1.

The Journal of biological chemistry - 24 Apr 2009

Hozoji Masako, Kimura Yasuhisa, Kioka Noriyuki, Ueda Kazumitsu

Abstract excerpt

ABCA1 plays a major role in cholesterol homeostasis and high density lipoprotein (HDL) metabolism. ABCA1 contains disulfide bond(s) between its N- and C-terminal halves, but it remains unclear whether disulfide bond formation is important for the functions of ABCA1 and which cysteines are involved in disulfide bond formation. To answer these questions, we constructed >30 ABCA1 mutants in which 16 extracellular...

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Identifiers

PMID: 19258317
DOI: 10.1074/jbc.M900580200
PMCID: PMC2670134

Genes

ABCA1
ECD

Provenance

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Formation of two intramolecular disulfide bonds is necessary for ApoA-I-dependent cholesterol efflux mediated by ABCA1.PMID 19258317Read ↗

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