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Article

Mutational studies of G553 in TM5 of ABCG2: a residue potentially involved in dimerization.

Biochemistry - 25 Apr 2006

Polgar Orsolya, Ozvegy-Laczka Csilla, Robey Robert W, Morisaki Kuniaki, Okada Masaki, Tamaki Akina, Koblos Gabriella, Elkind N Barry, Ward Yvona, Dean Michael, Sarkadi Balazs, Bates Susan E

Abstract excerpt

ABCG2 is an ATP-binding cassette half-transporter conferring resistance to chemotherapeutic agents such as mitoxantrone, irinotecan, and flavopiridol. With its one transmembrane and one ATP-binding domain, ABCG2 is thought to homodimerize for function. One conserved region potentially involved in dimerization is a three-amino acid sequence in transmembrane segment 5 (residues 552-554). Mutations in the...

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Share to ATP Binding Cassette Transporter, Subfamily G, Member 2
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16618113
DOI: 10.1021/bi0521590
PMCID: PMC2548280

Genes

ABCG2

Variants

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Mutational studies of G553 in TM5 of ABCG2: a residue potentially involved in dimerization.PMID 16618113Read ↗

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