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Article

Mutational analysis of threonine 402 adjacent to the GXXXG dimerization motif in transmembrane segment 1 of ABCG2.

Biochemistry - 16 Mar 2010

Polgar Orsolya, Ierano Caterina, Tamaki Akina, Stanley Bradford, Ward Yvona, Xia Di, Tarasova Nadya, Robey Robert W, Bates Susan E

Abstract excerpt

ABCG2 is an ATP-binding cassette half-transporter important in normal tissue protection, drug distribution, and excretion. ABCG2 requires homodimerization for function, though the mechanism for dimerization has not been elucidated. We conducted mutational analysis of threonine 402, three residues from the GXXXG motif in TM1, to study its potential role in ABCG2 dimerization (TXXXGXXXG). Single mutations to...

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Identifiers

PMID: 20088606
DOI: 10.1021/bi902085q
PMCID: PMC2836409

Genes

ABCG2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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