Article
Role of hepatocyte growth factor activator (HGF activator) in invasive growth of human glioblastoma cells in vivo.
International journal of cancer - 1 Feb 2006
Uchinokura Shunro, Miyata Shiro, Fukushima Tsuyoshi, Itoh Hiroshi, Nakano Shinichi, Wakisaka Shinichiro, Kataoka Hiroaki
Abstract excerpt
Hepatocyte growth factor/scatter factor (HGF/SF) is a multifunctional growth factor that is involved in invasive growth of tumor cells via its receptor MET, a protein product of c-met proto-oncogene. HGF activator (HGFA) is a serine proteinase responsible for the activation of proform of HGF/SF (proHGF/SF). In our study, we examined the effects of engineered expression of HGFA on 2 human glioblastoma cell lines...
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