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Article

Activation of p70S6K induces expression of matrix metalloproteinase 9 associated with hepatocyte growth factor-mediated invasion in human ovarian cancer cells.

Endocrinology - 1 May 2006

Zhou Hong Y, Wong Alice S T

Abstract excerpt

The expression of hepatocyte growth factor (HGF) receptor, encoded by the Met oncogene, is elevated in ovarian and a variety of cancers. Here we show that human ovarian cancer cells with high Met expression were more sensitive to the cell motility and invasion effect of HGF. Met down-regulation by small interfering RNAs or K252a resulted in reduced migration in response to HGF. The invasive/migratory phenotype...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16469801
DOI: 10.1210/en.2005-1404

Genes

HGF

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Activation of p70S6K induces expression of matrix metalloproteinase 9 associated with hepatocyte growth factor-mediated invasion in human ovarian cancer cells.PMID 16469801Read ↗

Exploiting p70 S6 kinase as a target for ovarian cancerSemantic proximity Read ↗

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Targeting the hepatocyte growth factor/Met pathway in cancer.Semantic proximity Read ↗

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HGF/c-MET Axis in Tumor Microenvironment and Metastasis FormationSemantic proximity Read ↗

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