Article
Glioma inhibition by HGF/NK2, an antagonist of scatter factor/hepatocyte growth factor.
Biochemical and biophysical research communications - 24 Jun 2000
Guerin C, Luddy C, Abounader R, Lal B, Laterra J
Abstract excerpt
Strategies that antagonize growth factor signaling are attractive candidates for the biological therapy of brain tumors. HGF/NK2 is a secreted truncated splicing variant and potential antagonist of scatter factor/hepatocyte growth factor (SF/HGF), a multifunctional cytokine involved in the malignant progression of solid tumors including glioblastoma. U87 human malignant glioma cells that express an autocrine...
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