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Article

Arsenic trioxide in front-line therapy of acute promyelocytic leukemia (C9710): prognostic significance of FLT3 mutations and complex karyotype.

Leukemia & lymphoma - 1 Jul 2014

Poiré Xavier, Moser Barry K, Gallagher Robert E, Laumann Kristina, Bloomfield Clara D, Powell Bayard L, Koval Gregory, Gulati Kabir, Holowka Nicholas, Larson Richard A, Tallman Martin S, Appelbaum Frederick R, Sher Dorie, Willman Cheryl, Paietta Elisabeth, Stock Wendy

Abstract excerpt

The addition of arsenic trioxide (ATO) to frontline therapy of acute promyelocytic leukemia (APL) has been shown to result in significant improvements in disease-free survival (DFS). FLT3 mutations are frequently observed in APL, but its prognostic significance remains unclear. We analyzed 245 newly diagnosed adult patients with APL treated on intergroup trial C9710 and evaluated previously defined biological and...

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Identifiers

PMID: 24160850
DOI: 10.3109/10428194.2013.842985
PMCID: PMC4273565

Genes

FLT3
PML
RARA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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