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Article

Apolipoprotein E epsilon4 allele differentiates the clinical response to donepezil in Alzheimer's disease.

Dementia and geriatric cognitive disorders - 1 Jan 2005

Bizzarro A, Marra C, Acciarri A, Valenza A, Tiziano F D, Brahe C, Masullo C

Abstract excerpt

The existence of an association between apolipoprotein E (APOE) and Alzheimer's disease (AD) has been reported in several studies. The possession of an ApoE epsilon4 allele is now considered a genetic risk factor for sporadic AD. There has been a growing agreement about the role exerted by the ApoE epsilon4 allele on the neuropsychological profile and the rate of cognitive decline in AD patients. However, a more...

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Source

Identifiers

PMID: 16103669
DOI: 10.1159/000087371

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Apolipoprotein E epsilon4 allele differentiates the clinical response to donepezil in Alzheimer's disease.PMID 16103669Read ↗

Effect of ApoE genotype on response to donepezil in patients with Alzheimer's disease.Semantic proximity Read ↗

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Apolipoprotein E epsilon4 allele differently affects the patterns of neuropsychological presentation in early- and late-onset Alzheimer's disease patients.Semantic proximity Read ↗

Neuropsychological function and apolipoprotein E genotype in the preclinical detection of Alzheimer's disease.Semantic proximity Read ↗

Cognitive impairment in Alzheimer's disease is modified by APOE genotype.Semantic proximity Read ↗

Cognitive deficits and polymorphism of apolipoprotein E in Alzheimer's disease.Semantic proximity Read ↗

Episodic memory changes are associated with the APOE-epsilon 4 allele in nondemented older adults.Semantic proximity Read ↗

Accelerated memory decline in Alzheimer's disease with apolipoprotein epsilon4 allele.Semantic proximity Read ↗

Clinical and neuropsychological characteristics in familial and sporadic Alzheimer's disease: relation to apolipoprotein E polymorphism.Semantic proximity Read ↗

Preclinical memory profile in Alzheimer patients with and without allele APOE-epsilon4.Semantic proximity Read ↗

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